However, some of the features in ASCII models are not as widely realized by the PK/PD community. The names of most NCA metrics estimated by the function of these packages are consistent with those used in WinNonlin®. Since WinNonlin is a validated software system, it is used widely for supporting pharmacokinetic assessments in regulatory compliant studies. These two packages are implemented in R and can accept a set of input arguments that allow for generation of NCA output. Install.packages( c( 'NonCompart', 'ncar')) library(NonCompart) library(ncar)ĭetailed documentation and examples for each package can be found on the online user manual in the CRAN repository (, ) or directly within the R console by entering ?function (e.g.?NonCompart,?ncar ).
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